I appreciate, as always, getting the news you bring on these very promising developments and also being reminded that some straightforward lifestyle choices within one’s own control can be helpful to increase healthspan. Interestingly, though, when responding to your questionnaire, I found the most applicable choice to be “unsure.” This has a good deal to do with my age (76) and the concomitant desire to keep tests and MD appointments to an absolute minimum.
What I see in older friends and am beginning to experience myself is that, as one grows older, interface with the medical establishment can quickly become a hamster wheel one must fight to get off. I hope therefore, as the advances you describe come to fruition, along with that will be some serious thought as to how to deliver the testing and healthcare required in a way that is far less episodic and uncoordinated than it is today. I envision, for example, geriatric health care centers with admin that makes it possible for older people to “one-stop-shop” several routine appointments in a single day. As it is, when I think about the possible need for ongoing tests and visits to monitor a health condition, I want to go running for the exits. But I will definitely continue to take my daily walks and eat a healthy diet inasmuch as is humanly possible!
Thanks for your feedback, Susan. There are plenty of ways discussed in the book that do not require ANY tests or appointments, but build on your walks and healthy diet. It's the longest chapter of the book. And it's never too late to promote healthspan.
What if you stop the clocks before age-related issues hit? Or reset them? The key is to find the right targets to do so.
My work (1976-2008) was in characterization of natural products for treating cancers, bio-energetics, and solution protein structure. It was a time where protein structures in the were rare commodities and natural products structures took many months. One set of compounds I worked on in the 80's and 90's were dolastatins and bryostatins. Potent anti-cancer agents but toxic as hell. They also were strong hdac inhibitors.
I morphed into working on the disease Spinal Muscular Atrophy (SMA) in 1998-2006. I have SMA and had to cut my career short in 2006 from my inevitable SMA downward path, some of it cognitive. I've also been on the SMA drugs Spinraza and Evrysdi that came from the early efforts. As a patient/researcher, I've been gotten to experience neuromuscular and cognitive declines and partial reversals in a very personal way.
So, where's the target to stop the aging clock? If you look at the various antibiotics, polyphenols, senolytics, etc., you'll find that the actual target may be the Survival of Motor Neuron Protein (SMN) and SMN genes that cause SMA. Resveratrol, VPA, rapamycin, various polyphenols, EGCG, curcumin all increase SMN expression. SMN has critical roles in rna biogenesis, translation and transcription. SMN is a key protein in axon transport and maintaining motor neurons and neural plates. SMN is increasingly being shown to have multiple tissue-specific roles. SMA offers a wealth of insights for individuals involved in age-related disease. The genetics are complicated (and why we have human brains). I'm outlining how SMN may play a key role in aging in an upcoming conference and followup publication.
For now, I'll leave it at solving the aging issue may be simpler than we think.
My husband was diagnosed with MSA 2 years ago. His symptoms started approximately over ten years ago with REM. Serious bladder issues, and UTIs about 4 years ago. Three years ago, he began experiencing problems with his balance, handwriting, and low blood pressure. This year, the movement disorders took over his body, and he was confined to a wheelchair, (used a walker prior for almost a year). He’s progressively declined very quickly. There was less interaction and very little conversation he was bedridden. His swallowing was getting worse & was taking him longer to eat. My husband has been doing the MSA-5 herb Protocol from www. limitlesshealthcenter. com for about 5 months and it has been a life changer Within the first 3 months, he could write and walk again! it’s done him a lot of good in terms of balance and ability to walk, which has been very noticeable. He can now write without his hands shaking. he can feel his strength again. We feel very fortunate to have learned about the MSA-5 herb formula for Multiple System Atrophy
I'll check out your book, Dr. Topol. It represents taking the first step of what we know and what is possible today. I'll do all I can, but for items that hinge on others, accessibility and affordability is another question entirely.
I appreciate, as always, getting the news you bring on these very promising developments and also being reminded that some straightforward lifestyle choices within one’s own control can be helpful to increase healthspan. Interestingly, though, when responding to your questionnaire, I found the most applicable choice to be “unsure.” This has a good deal to do with my age (76) and the concomitant desire to keep tests and MD appointments to an absolute minimum.
What I see in older friends and am beginning to experience myself is that, as one grows older, interface with the medical establishment can quickly become a hamster wheel one must fight to get off. I hope therefore, as the advances you describe come to fruition, along with that will be some serious thought as to how to deliver the testing and healthcare required in a way that is far less episodic and uncoordinated than it is today. I envision, for example, geriatric health care centers with admin that makes it possible for older people to “one-stop-shop” several routine appointments in a single day. As it is, when I think about the possible need for ongoing tests and visits to monitor a health condition, I want to go running for the exits. But I will definitely continue to take my daily walks and eat a healthy diet inasmuch as is humanly possible!
Thanks for your feedback, Susan. There are plenty of ways discussed in the book that do not require ANY tests or appointments, but build on your walks and healthy diet. It's the longest chapter of the book. And it's never too late to promote healthspan.
Hi Dr. Topol,
What if you stop the clocks before age-related issues hit? Or reset them? The key is to find the right targets to do so.
My work (1976-2008) was in characterization of natural products for treating cancers, bio-energetics, and solution protein structure. It was a time where protein structures in the were rare commodities and natural products structures took many months. One set of compounds I worked on in the 80's and 90's were dolastatins and bryostatins. Potent anti-cancer agents but toxic as hell. They also were strong hdac inhibitors.
I morphed into working on the disease Spinal Muscular Atrophy (SMA) in 1998-2006. I have SMA and had to cut my career short in 2006 from my inevitable SMA downward path, some of it cognitive. I've also been on the SMA drugs Spinraza and Evrysdi that came from the early efforts. As a patient/researcher, I've been gotten to experience neuromuscular and cognitive declines and partial reversals in a very personal way.
So, where's the target to stop the aging clock? If you look at the various antibiotics, polyphenols, senolytics, etc., you'll find that the actual target may be the Survival of Motor Neuron Protein (SMN) and SMN genes that cause SMA. Resveratrol, VPA, rapamycin, various polyphenols, EGCG, curcumin all increase SMN expression. SMN has critical roles in rna biogenesis, translation and transcription. SMN is a key protein in axon transport and maintaining motor neurons and neural plates. SMN is increasingly being shown to have multiple tissue-specific roles. SMA offers a wealth of insights for individuals involved in age-related disease. The genetics are complicated (and why we have human brains). I'm outlining how SMN may play a key role in aging in an upcoming conference and followup publication.
For now, I'll leave it at solving the aging issue may be simpler than we think.
20+ studies have found that lifespan or healthspan is increased by:
Vitamin D or Omega-3 or Magnesium
https://vitamindwiki.com/tiki-index.php?page_id=14099
Also:
Google Scholar has 127,000 hits for (LONGEVITY OR HEALTHSPAN) VITAMIN D
My husband was diagnosed with MSA 2 years ago. His symptoms started approximately over ten years ago with REM. Serious bladder issues, and UTIs about 4 years ago. Three years ago, he began experiencing problems with his balance, handwriting, and low blood pressure. This year, the movement disorders took over his body, and he was confined to a wheelchair, (used a walker prior for almost a year). He’s progressively declined very quickly. There was less interaction and very little conversation he was bedridden. His swallowing was getting worse & was taking him longer to eat. My husband has been doing the MSA-5 herb Protocol from www. limitlesshealthcenter. com for about 5 months and it has been a life changer Within the first 3 months, he could write and walk again! it’s done him a lot of good in terms of balance and ability to walk, which has been very noticeable. He can now write without his hands shaking. he can feel his strength again. We feel very fortunate to have learned about the MSA-5 herb formula for Multiple System Atrophy
I'll check out your book, Dr. Topol. It represents taking the first step of what we know and what is possible today. I'll do all I can, but for items that hinge on others, accessibility and affordability is another question entirely.