One of your very best interviews! For you and Jim's interpretation and speaking as a reasonably well educated individual with a positive bias toward Engineering, and a small philanthropic funder of same (let me catch my breath) I want to say that my own takeaways from this interview can be distilled to appreciation of the enormity of the challenges met by a brilliant group of scientists and engineers. The brilliance of the insight that it was necessary to crack the black box problem and get at the rationales employed and to bring in and repurpose Alphafold. What a model of scientific advancement! To me the idea of circling back and revisiting and repurposing old technologies and ideas is so potentially fruitful in so many areas. Now I'll stop- it's time for me to circle back and re-read this article again!
Fascinating. One question: is it possible Jim Collins' work would help Crohns patients? It caught my attention when Jim described the potential use for helping soldiers' guts to acclimate to new environments, with halicin attacking the pathogens and leaving commensals alone.
Crohns is one of those conditions that Pharma has developed hyper-expensive and difficult to deliver solutions (Humira, etc). Is it possible something like halicin would be a more affordable and accessible treatment for Crohns patients, perhaps? This is one of those 'broken' areas where capitalism has really failed us, with Crohns only affecting a tiny percentage of the population.
One of your very best interviews! For you and Jim's interpretation and speaking as a reasonably well educated individual with a positive bias toward Engineering, and a small philanthropic funder of same (let me catch my breath) I want to say that my own takeaways from this interview can be distilled to appreciation of the enormity of the challenges met by a brilliant group of scientists and engineers. The brilliance of the insight that it was necessary to crack the black box problem and get at the rationales employed and to bring in and repurpose Alphafold. What a model of scientific advancement! To me the idea of circling back and revisiting and repurposing old technologies and ideas is so potentially fruitful in so many areas. Now I'll stop- it's time for me to circle back and re-read this article again!
This is an excellent case study which illustrates and actually lets you visualize the dramatic advances (and challenges) in AI-driven drug design.
Fascinating. One question: is it possible Jim Collins' work would help Crohns patients? It caught my attention when Jim described the potential use for helping soldiers' guts to acclimate to new environments, with halicin attacking the pathogens and leaving commensals alone.
Crohns is one of those conditions that Pharma has developed hyper-expensive and difficult to deliver solutions (Humira, etc). Is it possible something like halicin would be a more affordable and accessible treatment for Crohns patients, perhaps? This is one of those 'broken' areas where capitalism has really failed us, with Crohns only affecting a tiny percentage of the population.