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Very impressive increase in adenoma detection. The obvious question is how this translates to decreasing the risk of fatal colorectal cancer. In some studies detecting low grade adenomas does not lower the mortality rate. This technology is in its infancy, and we will need to follow-up with more studies.

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Agree, thanks, Mark. This meta-analysis was far more positive than the 21 trials reviewed in Annals of Internal Medicine https://www.acpjournals.org/doi/10.7326/M22-3678

with respect to adenomatous polyps, but the question of changing the natural history of colon cancer with A.I. detection support will take long term follow-up in large trials.

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Is AI guided colonoscopy being used in clinical practice in the US, and if so, by whom?

There is no public access to ADR rates, which we know are very variable by individual gastroenterologists. My group is attempting to guide patients to high quality GI's for their colonscopies as a component of a comprehensive oncology program and this is one of the largest gaps I'm trying to solve for.

NIce review of the meta analysis - thanks!

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