Hi Dr. T: Thanks for your great work. Can you speculate on how GLP-1 medications impact Parkinson’s when they don’t cross the blood brain barrier? Are there any other connections between, say, gut biome neurology, and extrapyramidal function? Thanks- Greg Sazima, MD
Yes, as Dan Drucker conveyed (in the companion podcast) from his experimental model work and that of others there is crosstalk from the gut to brain without invoking direct GLP-1 neuronal interaction for suppression of brain inflammation.
The shortage of these medications is getting pretty intense, with many of my patients scrambling to find refills and many having to stop cold turkey. The good clinical news keeps coming, and I believe the theoretical increased risk of pancreatic cancers has not materialized. Still waiting on definitive news about thyroid tumors, though this also seems unlikely outside of rat trials.
Some serious GI side effects for many, but also some serious success stories for many more.
Bravo indeed to these individuals, as these meds are now a commonplace in primary care treatment repertoires.
I had cold-turkey cutoff three times in the past 12 months. the complicated world of pharmacy distribution, pharma manufacturing and the overextend hypes of quick-fix social influencers.
As a research-based MD/PhD, these drugs are quite exciting, but it is clear that we do not understand the mechanism of many of their actions.
While this is not the place to present detailed data, there are many instances where it is clear that there are environmental factors, presumably small molecules, affecting malignancy rates and other bodily functions.
Given the fact that we now know that very small amounts of the right chemical can dramatically affect physiological function, I have long speculated that there may be compounds in our environment that do the opposite of the GLP-1's. It would be extremely interesting to know the total load of metabolic modifiers that we ingest or breathe every day. I give modifiers of the Cytochrome P450 system in food as an example.
My Partner, who is 66 years old, was diagnosed with Parkinson's disease last year. We noticed that he was experiencing hallucinations, slow movement, disturbed sleep, and twitchy hands and legs when at rest. He had to stop taking pramipexole (Sifrol), carbidopa/levodopa, and 2 mg of biperiden because of side effects. Our family doctor recommended a PD-5 treatment from naturalherbscentre. com, which my husband has been undergoing for several months now. Exercise has been very beneficial. He has shown great improvement with the treatment thus far. He is more active now, does more, and feels less apathetic. He has more energy and can do more activities in a day than he did before. As far as tremors I observe a progress, he improved drastically. I thought I would share my husband's story in case it could be helpful, but ultimately you have to figure out what works best for you. Salutations and well wishes
Hi Dr. T: Thanks for your great work. Can you speculate on how GLP-1 medications impact Parkinson’s when they don’t cross the blood brain barrier? Are there any other connections between, say, gut biome neurology, and extrapyramidal function? Thanks- Greg Sazima, MD
Yes, as Dan Drucker conveyed (in the companion podcast) from his experimental model work and that of others there is crosstalk from the gut to brain without invoking direct GLP-1 neuronal interaction for suppression of brain inflammation.
The shortage of these medications is getting pretty intense, with many of my patients scrambling to find refills and many having to stop cold turkey. The good clinical news keeps coming, and I believe the theoretical increased risk of pancreatic cancers has not materialized. Still waiting on definitive news about thyroid tumors, though this also seems unlikely outside of rat trials.
Some serious GI side effects for many, but also some serious success stories for many more.
Bravo indeed to these individuals, as these meds are now a commonplace in primary care treatment repertoires.
I had cold-turkey cutoff three times in the past 12 months. the complicated world of pharmacy distribution, pharma manufacturing and the overextend hypes of quick-fix social influencers.
exactly. putting out fires like this all day every day in primary care. usually I can't help either. it is really bad right now!
As a research-based MD/PhD, these drugs are quite exciting, but it is clear that we do not understand the mechanism of many of their actions.
While this is not the place to present detailed data, there are many instances where it is clear that there are environmental factors, presumably small molecules, affecting malignancy rates and other bodily functions.
Given the fact that we now know that very small amounts of the right chemical can dramatically affect physiological function, I have long speculated that there may be compounds in our environment that do the opposite of the GLP-1's. It would be extremely interesting to know the total load of metabolic modifiers that we ingest or breathe every day. I give modifiers of the Cytochrome P450 system in food as an example.
My Partner, who is 66 years old, was diagnosed with Parkinson's disease last year. We noticed that he was experiencing hallucinations, slow movement, disturbed sleep, and twitchy hands and legs when at rest. He had to stop taking pramipexole (Sifrol), carbidopa/levodopa, and 2 mg of biperiden because of side effects. Our family doctor recommended a PD-5 treatment from naturalherbscentre. com, which my husband has been undergoing for several months now. Exercise has been very beneficial. He has shown great improvement with the treatment thus far. He is more active now, does more, and feels less apathetic. He has more energy and can do more activities in a day than he did before. As far as tremors I observe a progress, he improved drastically. I thought I would share my husband's story in case it could be helpful, but ultimately you have to figure out what works best for you. Salutations and well wishes