How Well will Our Immune System Respond?
A major hospitality industry trade show just occurred in Las Vegas. A colleague arrived in the US from Europe for the show, didn't feel well, and tested positive for COVID. They, responsibly, remained in their hotel room until testing negative, and missed the entire show. In a conversation with another colleague who knew people who attended came reports of others who came home from the show feeling 'not great' and tested positive. The Show has no contact tracing requirement. As has been the case from the start of COVID, events are not checking to see if hotels' and convention center and other service employees are reporting symptoms of positive tests. It would be great if events do occur they announce "We're a mask-friendly event. Ensure others' safety and your own." Our household is still masking, even in our high-rise, to use the elevator to get the mail even tho' we are fully up-to-date on vaccinations.
I received COVID vaccine recently and three weeks later got COVID. Was fairly sick but seem to be recovering. First time with COVID. Had all other COVID vaccines and boosters and had been pretty careful with masking. Doctor thinks I got one of newer variants that escaped vaccine. This thing is definitely not over.
As far as "non-pharmacologic means of preventing infections help work against all strains of this and other respiratory viruses that are out there now (including flu and RSV)." I think of masking, fresh air, air filtration and proactive testing. Are there other approaches you have in mind? Thanks for your posts!
I’m still using viraleze anti viral nasal spray, plus vaccines, am trying to get the latest version of Novavax here in Australia- I’ve had Covid once (when I stopped using viraleze!) caught it at a health resort 🤦♀️ Dr Topol which vaccine would you recommend, this will be my 5th, I’m a 62 yr old with heart issues. Love what you are doing.
1. What progress has there been on an all:-variant vaccine or nasal spray?
2. After how many significant mutations will this virus have departed so far from the original 2019 ancestor as to be a fundamentally new virus?
Are you familiar with the work of Geert Vanden Bossche, author of "The Inescapable Immune Escape Pandemic"? He's a virologist who previously worked with the Bill & Melinda Gates Foundation, GAVI, and the WHO with regard to vaccine development, and since March of 2021 has been warning that vaccinating in the face of a pandemic is a terrible strategy because some peope will get infected between the time of their first shot and the time their immunity is mature, about two weeks after their second shot - and this will create an immunological environment in which escape variants will flourish until one arises which is deadly for the vaccinated (he's now saying mostly those who received two shots and weren't infected beforehand), against which they will have no immunological defense. I can't judge his complicated science but he sounds both extremely knowledgeable and honest, so I find it discouraging that I haven't seen any comprehensive reviews of his book or interviews.
Would you recommend the current vaccine if you have been dealing with Long Covid for 9 months and are over 65?
Dear Dr Topol
I have been very troubled that US and other regulatory bodies have largely ignored T cell contributions of protection both CD4 and CD8. In addition they also seem to ignore IgA and quantitative measures of Memory across the B cell and T cell spectrum. I am both saddened and dismayed by this lack of scientific rigor and accuracy whereas Human Immune Monitoring is standard across many Universities and Private Industry. Vaccines for infectious disease deserve the same level (or higher)
Of scientific truth as Cancer and Autoimmunity.
Your thoughts most welcome!
Ps We met and served together on a science board a long time ago and greatly appreciated.
Can you comment on the use by some of anti-platelets and anti-coagulants in treating long-Covid and it's potential efficacy in treating the virus itself?